miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively
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چکیده
منابع مشابه
miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively
miRNAs typically downregulate the expression of target genes by binding to their 3'UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3'UTR of hTERT mRNA and have opposite effects on the expression and function of hTERT in human cervical cancer cells. Furthermore, G-rich RNA sequence binding fact...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep15793